2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W089856R
    Chlorobutanol hemihydrate (Standard) 6001-64-5
    Chlorobutanol (hemihydrate) (Standard) is the analytical standard of Chlorobutanol (hemihydrate). This product is intended for research and analytical applications. Chlorobutanol hemihydrate is a pharmaceutical preservative. Chlorobutanol hemihydrate is active against a wide variety of Gram-positive and Gram-negative bacteria, and several mold spores and fungi. Chlorobutanol hemihydrate is widely used in food and cosmetic industry.
    Chlorobutanol hemihydrate (Standard)
  • HY-W201842B
    Octamylamine hydrochloride 5964-56-7 98%
    Octamylamine hydrochloride is an anticholinergic and antispasmodic agent.
    Octamylamine hydrochloride
  • HY-W278072R
    Calcium Channel antagonist 1 (Standard) 43067-01-2
    Calcium Channel antagonist 1 (Standard) is the analytical standard of Calcium Channel antagonist 1. This product is intended for research and analytical applications. Calcium Channel antagonist 1 is an antagonist of Calcium Channel Calcium Channel antagonist 1 has the potential for the research of neurology disease.
    Calcium Channel antagonist 1 (Standard)
  • HY-W415121R
    Bupivacaine hydrochloride monohydrate (Standard) 73360-54-0
    Bupivacaine (hydrochloride monohydrate) (Standard) is the analytical standard of Bupivacaine (hydrochloride monohydrate). This product is intended for research and analytical applications. Bupivacaine hydrochloride monohydrate is a NMDA receptor inhibitor. Bupivacaine hydrochloride monohydrate can block sodium, L-calcium, and potassium channels. Bupivacaine hydrochloride monohydrate potently blocks SCN5A channels with the IC50 of 69.5 μM. Bupivacaine hydrochloride monohydrate can be used for the research of chronic pain.
    Bupivacaine hydrochloride monohydrate (Standard)
  • HY-W424792A
    O-Desmethyl Brinzolamide hydrochloride 2967475-56-3 98%
    O-Desmethyl Brinzolamide hydrochloride (compound 6a), an active metabolite of Brinzolamide, is a carbonic anhydrase (CA) inhibitor with a Kd of 0.136 nM for CA II and an IC50 of 165 nM for CA IV.
    O-Desmethyl Brinzolamide hydrochloride
  • HY-W670564A
    (4S)-10-Nor-calamenen-10-one 1270089-06-9 98%
    (4S)-10-Nor-calamenen-10-one (Compound 15) enhances LPS-induced NO production by microglia. (4S)-10-Nor-calamenen-10-one is an eudesmane sesquiterpene that can be isolated from Alpinia oxyphylla.
    (4S)-10-Nor-calamenen-10-one
  • HY-W725190A
    Piperidylthiambutene 54160-31-5 98%
    Piperidylthiambutene is a potent µ-opioid receptor (MOR) agonist with a Ki of 2.75 nM. Piperidylthiambutene exhibits analgesic and antitussive properties and can be utilized in relevant research.
    Piperidylthiambutene
  • HY-W726667A
    (R)-(-)-Citramalic acid lithium 2319882-36-3 98%
    (R)-(-)-Citramalic acid ((R)-Citramalate) lithium, a lithium salt of Citramalic acid, is the R enantiomer of Citramalic acid lithium. (R)-(-)-Citramalic acid lithium is involved in the metabolism of glutamate through the methylaspartate pathway. (R)-(-)-Citramalic acid lithium is promising for research of neurological disorders.
    (R)-(-)-Citramalic acid lithium
  • HY-W749852A
    Xanthine sodium, for cell culture 1196-43-6 98%
    Xanthine sodium, for cell culture, a plant alkaloid found in tea, coffee, and cocoa, is a mild stimulant of the central nervous system. Xanthine sodium, for cell culture also acts as an intermediate product on the pathway of purine degradation.
    Xanthine sodium, for cell culture
  • HY-W762011R
    BDE 47 (Standard) 5436-43-1
    BDE 47 (Standard) is the analytical standard of BDE 47. This product is intended for research and analytical applications. BDE 47 targets mitochondria, inhibits mitochondrial oxidative phosphorylation (OXPHOS), decreases mitochondrial membrane potential (MMP) and induces apoptosis in embryonic cell. BDE 47 induces the generation of ROS, and activates the JNK signaling pathway. BDE 47 exhibits embryonic developmental toxicity in zebrafish.
    BDE 47 (Standard)
  • HY-Y0966S11
    Glycine-13C2,15N,d2 1984075-49-1 98%
    Glycine-13C2,15N,d2 is the deuterium, 13C and 15N labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.
    Glycine-13C2,15N,d2
  • HY-109101AS1
    Risdiplam-hydroxylate-d3 98%
    Risdiplam-hydroxylate-d3 is a Risdiplam-hydroxylate tritium substitute. Risdiplam (RG7916) is an orally administered, centrally and peripherally distributed SMN2 pre-mRNA splicing modifier that increases survival motor neuron (SMN) protein levels.
    Risdiplam-hydroxylate-d3
  • HY-109101AS2
    Risdiplam-hydroxylate-d6 98%
    Risdiplam-hydroxylate-d6 is a Risdiplam-hydroxylate tritium substitute. Risdiplam (RG7916) is an orally administered, centrally and peripherally distributed SMN2 pre-mRNA splicing modifier that increases survival motor neuron (SMN) protein levels.
    Risdiplam-hydroxylate-d6
  • HY-113468AS1
    3-O-Methyldopa-d3 hydrate 98%
    3-O-Methyldopa-d3 (hydrate) is the deuterium labeled 3-O-Methyldopa. 3-O-Methyldopa (3-Methoxy-L-tyrosine) hydrate is a metabolite of L-DOPA (HY-N0304) that can cross the blood-brain barrier (BBB). 3-O-Methyldopa hydrate inhibits the astrocyte-mediated protective effect of L-DOPA (HY-N0304) on dopaminergic neurons. In addition, 3-O-Methyldopa hydrate has certain antidepressant and neuroprotective activities. 3-O-Methyldopa hydrate can be used in the research of nervous system diseases such as depression and Parkinson's disease.
    3-O-Methyldopa-d3 hydrate
  • HY-121883SS5
    Lignoceric acid-d9 2415226-90-1 ≥98.0%
    Lignoceric acid-d9 is the deuterium labeled Lignoceric acid. Lignoceric acid (Tetracosanoic acid) is a 24-carbon saturated (24:0) fatty acid, which is synthesized in the developing brain. Lignoceric acid is also a by-product of lignin production. Lignoceric acid can be used for Zellweger cerebro‐hepato‐renal syndrome and adrenoleukodystrophy research.
    Lignoceric acid-d9
  • HY-W001158S1
    N,N-Dimethylglycine-d3 hydrochloride 1219795-14-8 98%
    N,N-Dimethylglycine-d3 (Dimethylglycine-d3) hydrochloride is the deuterium labeled N,N-Dimethylglycine hydrochloride (HY-W001158). N,N-Dimethylglycine (Dimethylglycine) hydrochloride, a natural N-methylated glycine, is a nutrient supplement and acts as an NMDAR glycine site partial agonist. N,N-Dimethylglycine hydrochloride is a methyl donor that can improve immunity, act as an antioxidant to prevent oxidative stress, and scavenge excess free radicals. N,N-Dimethylglycine hydrochloride has antidepressant-like and surfactant effects.
    N,N-Dimethylglycine-d3 hydrochloride
  • HY-W002112S1
    (±)-Nornicotine-d7 98%
    (±)-Nornicotine-d7 is the deuterium labeled (±)-Nornicotine (HY-W002112). (±)-Nornicotine is a major metabolite of Nicotine. (±)-Nornicotine is a partial nAChRs agonist, specifically activating receptor subtypes containing α7 and α6 subunits. (±)-Nornicotine disrupts β-catenin and ZO-1, and induces F-actin depolymerization. (±)-Nornicotine supports self-administration behavior. (±)-Nornicotine can be used in the research of atherosclerosis, Alzheimer's disease, and schizophrenia.
    (±)-Nornicotine-d7
  • HY-W008253S3
    5-Hydroxyindole-3-acetic acid-13C6 2733322-34-2 98%
    5-Hydroxyindole-3-acetic acid-13C6 is the 13C-labeled 5-Hydroxyindole-3-acetic acid. 5-Hydroxyindole-3-acetic acid is the main metabolite of serotonin or metanephrines, which can be used as a biomarker of neuroendocrine tumors.
    5-Hydroxyindole-3-acetic acid-13C6
  • HY-W009247S1
    N-Desmethylolanzapine-d8 hydrochloride 2711722-81-3 98%
    N-Desmethylolanzapine-d8 hydrochloride (N-Demethylolanzapine-d8 hydrochloride) is the deuterium labeled N-Desmethylolanzapine (HY-W009247). N-Desmethylolanzapine is an antipsychotic drug. The formation of N-Desmethylolanzapine correlates with the level and activity of human liver flavin-containing monooxygenase (FMO3). N-Desmethylolanzapine can be used in the study of antipsychotic drugs .
    N-Desmethylolanzapine-d8 hydrochloride
  • HY-W011051S2
    2-Arachidonoylglycerol-d11 2260670-54-8 98%
    2-Arachidonoylglycerol-d11 is deuterium labeled 2-Arachidonoylglycerol.2-Arachidonoylglycerol is a second endogenous cannabinoid ligand in the central nervous system.
    2-Arachidonoylglycerol-d11
Cat. No. Product Name / Synonyms Application Reactivity